Dispensing Instruments

Innovadyne Technologies, Inc. offers best-in-class liquid-handling instruments providing non-contact, low-volume (nanoliter to microliter) aspirate-and-dispense solutions to end users and leading lab automation companies worldwide. Our products serve the HTS, Genomics and Proteomics markets to enable miniaturized screening assays, bead and cell-based assays, protein crystallization screens, and low-volume genomic amplification protocols in 96, 384, 1536, and 3456 formats. Our products offer a robust and low-maintenance means of achieving assay volume reduction without compromising precision or accuracy.

Nanodrop™ I

The Nanodrop I is a single plate, 8-channel, high-precision pipetting instrument that enables rapid, non-contact dispensing of reagents into 96-, 384-, and 1536-well plate formats. It has a dispense range from 100 nL through 40 µL, with CVs below 5%, measured across 8 tips. It is readily integrated into standard instrumentation systems.

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Nanodrop ExtY

Utilizing the Nanodrop series fluidics module, the Nanodrop ExtY’s design allows two sets of 4 tips each to dispense reagent to all wells of a standard SBS plate, facilitating rapid dispense of two reagents. Additionally, there are 4 tips that can access any well position for dispensing rare samples and reagents.

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Nanodrop II

The Nanodrop II is a complete solution for low volume, high-precision pipetting. The system can be configured with one or two plate positions to enable applications such as assay miniaturization, method development, PCR reaction setup, and protein crystallography. As with the ExtY, 4 of the tips can individually access any well of a standard SBS plate, enabling complex method development and design.

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Nanodrop Express

The 16-channel Nanodrop™ Express is our fastest benchtop system -- a complete high-throughput solution for low volume, high-precision pipetting. The Nanodrop Express doubles the dispense capacity and halves the aspirate time of a Nanodrop II. The Nanodrop Express can be configured with one- or two-plate stage modules, and interchangeable 1x16 or 2x8 tip heads specialized for reagent dispensing and 96-to-384 transfers, respectively.

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Screenmaker 96+8™

The Screenmaker 96+8 incorporates the company's non-contact dispense technology, coupled with traditional syringe dispensing. The unique combination of a 96-channel, non-contact dispense head coupled to an 8-channel head makes the instrument ideally suited for protein crystallography.

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Platemaker HTS™

Innovadyne’s flagship Platemaker HTS™ instrument is designed to offer both high-throughput liquid transfers and reagent additions on one integrated platform. Employing our patented valve-free flow path, the unique instrument combines a 96-channel, non-contact dispense head coupled to an 8-channel, non-contact/contact dispense capability enabling a variety of applications including PCR/Sequencing setup, HTS, and protein crystallography. Individual channel control makes applications such as normalization, dispensing of gradients, multiplexing and the dispensing of unique plate maps possible.

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Product Specifications

	Nanodrop I	Nanodrop ExtY	Nanodrop II	Nanodrop Express	Screenmaker 96+8	Platemaker HTS
Plate Positions	1	1	2	1 or 2	5	5
8-Tip Head	Yes	Yes	Yes	-	Yes	Yes
16-Tip Head	-	-	-	Yes	-	-
96-Tip Head	-	-	-	-	Yes	Yes
Syringe Channels	8	8	8	16	16	104
1, 4 Or 8-Tip Bulk Reagent Additions To All Positions	-	Yes	Yes	Yes	Yes	Yes
Plate Formats	96/384/1536 std	96/384/1536 std, low profile, Xtal, and deep well	96/384/1536 std, low profile, Xtal, and deep well	96/384/1536 std, low profile, Xtal, and deep well	96/384/1536 std, low profile, Xtal, and deep well	96/384/1536 std, low profile, Xtal, and deep well
Return-To-Spot Accuracy	0.1 mm	0.1 mm	0.1 mm	0.1 mm	0.1 mm	0.1 mm
Aspiration Range, 8-Tip Head	0.1-500µL	0.1-500µL	0.1-500µL	0.1-500µL	0.1-500µL	0.1-500µL
Aspiration Range, 96-Tip Head	-	-	-	-	0.1-125µL	0.1-500µL
Dispensing Range (8-Tip Non-Contact)	0.1-40µL	0.1-40µL	0.1-40µL	0.1-80µL	0.1-40µL	0.1-40µL
Dispensing Range (8-Tip Contact)	-	25-500µL	25-500µL	25-500µL	25-500µL	25-500µL
Dispensing Range (96-Tip Non-Contact)	-	-	-	-	0.1-125µL	0.1-80µL
Dispensing Precision, 8-Tip Head	CV<10% at 100nL CV<7% at 200nL CV<5% at 1µL	CV<10% at 100nL CV<7% at 200nL CV<5% at 1µL	CV<10% at 100nL CV<7% at 200nL CV<5% at 1µL	CV<10% at 100nL CV<7% at 200nL CV<5% at 1µL	CV<10% at 100nL CV<7% at 200nL CV<5% at 1µL	CV<10% at 100nL CV<7% at 200nL CV<5% at 1µL
Dispensing Precision, 96-Tip Head	-	-	-	-	CV<15% at 100nL CV<10% at 200nL CV<5% at 1µL	CV<15% at 100nL CV<10% at 200nL CV<5% at 1µL
Dispensing Accuracy, 8-Tip Head	±10% at 100nL ±7% at 200nL ±5% at >1 µL	±10% at 100nL ±7% at 200nL ±5% at >1 µL	±10% at 100nL ±7% at 200nL ±5% at >1 µL	±10% at 100nL ±7% at 200nL ±5% at >1 µL	±10% at 100nL ±7% at 200nL ±5% at >1 µL	±10% at 100nL ±7% at 200nL ±5% at >1 µL
Dispensing Accuracy, 96-Tip Head	-	-	-	-	±10% at 100 - 500nL ±5% at >1 500nL	±10% at 100nL ±7% at 200nL ±5% at >1 µL
Dead Volume, 8-Tip head	1.5µL/channel at 1µL across 384-well plate	1.5µL/channel at 1µL across 384-well plate	1.5µL/channel at 1µL across 384-well plate	1.5µL/channel at 1µL across 384-well plate	1.5µL/channel at 1µL across 384-well plate	1.5µL/channel at 1µL across 384-well plate
Dead Volume, 96-Tip head	-	-	-	-	<1µL/channel	<1µL/channel
Syringe Capacity	500, 1000µL	500, 1000µL	500, 1000µL	500, 1000µL	500, 1000µL	500, 1000µL
Cycle Time, 8-Tip Head	5s/96-well plate 10s/384-well plate 15s/1536-well plate	20s/transfer <60s 1µL reagent addition (1tip/96-well plate) <17s 1µL reagent addition (8tips /1536-well plate)	20s/transfer <60s 1µL reagent addition (1tip/96-well plate) <17s 1µL reagent addition (8tips /1536-well plate)	10s/transfer (other times to be provided)	20s/transfer <60s 1µL reagent addition (1tip/96-well plate) <17s 1µL reagent addition (8tips /1536-well plate)	20s/transfer <60s 1µL reagent addition (1tip/96-well plate) <17s 1µL reagent addition (8tips /1536-well plate)
Cycle Time, 96-Tip Head	-	-	-	-	180 s/transfer (includes wash)	45 s/transfer (includes wash)

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