Nanodrop™ Express

Innovadyne Technologies introduces the 16-channel Nanodrop™ Express, our fastest benchtop system -- a complete high-throughput solution for low volume, high-precision pipetting.

The Nanodrop Express doubles the dispense capacity and halves the aspirate time of a Nanodrop II. The Nanodrop Express can be configured with one- or two-plate stage modules, and interchangeable 1x16 or 2x8 tip heads specialized for reagent dispensing and 96-to-384 transfers, respectively. For reagent addition, 8 individual tips can access any well of a standard SBS plate, enabling complex method development and design.

The Nanodrop Express aspirates and dispenses a broad range of liquids, including DMSO, and features the Nanobuilder© software system that enables a wide range of applications and data manipulation. Innovadyne’s patented technology isolates the solenoid dispense actuators from the sample path. This assures long life and easy, low-cost maintenance, even with regular use of difficult suspensions such as proteins, cells and YOx beads.

Features

Non-contact and contact dispense
Exceptional dynamic range (nanoliter to milliliter)
Interchangeable 1x16 tip (for reagent dispensing and 384+ well plates) and 2x8 tip (for 96-to-384 transfers) heads
Multiple reagent addition
Aspirate and dispense with individual channel articulation
Sample transfer and bulk reagent addition on the same platform
Valve-free fluid path for outstanding reliability
FEP, SS, sapphire wetted parts compatible with commonly used solvents
96-, 384-, and 1536-well plate formats; deep-well and crystal plates supported
Modular, raised, removable plate nests enable flexible configuration
1-plate nest and 2-plate nest stages available
Easy to program, easy to automate
Simple cleaning and maintenance

Applications

Protein Crystallography

Coarse and fine screen creation
Mother liquor transfer
Protein additions
Hanging and sitting drop

HTS

Sample transfer
Reagent addition

Assay Development - Miniaturization

Cell-based Assays

Cell plating
Cell dosing

Bead-based Assays

SPA bead assays
YOx bead assays
Polystyrene bead assays

PCR

Template transfers
Cocktail addition
Sequencing

MALDI Plate Spotting

Oligo QC
Proteins

Performance Specifications

Plate Formats	96, 96 deep well, 384, 384 deep well, 1536, 1536 low profile, crystallography plates (Note: 96-well plates require the 2x8 head)
Plate Positions	1 or 2
Return to Spot Accuracy	0.1 mm
Dispense Functions	Compound transfer (contact/non-contact), single tip reagent addition, 8-tip reagent addition
Aspirate Modes	All the same volumes, independent
Dispense Modes	All the same volumes, independent
Aspiration Range	0.1 - 500 µL
Dispensing Range	0.1 - 80 µL (non-contact) 25 - 500 µL (contact)
Dispensing Precision	CV ≤ 10% at 100 nL CV ≤ 7% at 200 nL CV ≤ 5% at 1 µL
Dispensing Accuracy	±10% at 100 nL ±7% at 200 nL ±5% at 1 µL
Dead Volume	1.44 µL/channel at 1 µL across 384-well plate
Syringe Capacity	500, 1000 µL
Cycle Time	10 s/transfer (2 reagent addition and 384/1536 1 reagent addition times forthcoming)

Configuration Options

Part No.	Description
12043	Nanodrop Express fluidics module (required)
11460	1-plate stage module
11245	2-plate stage module
-	1x16-tip head
-	2x8-tip head

Technical Specifications

Dimension	Fluidics Module	1-Plate Stage Module	2-Plate Stage Module
Height	33.0 cm (13 in)	32.3 cm (12.7 in)	32.3 cm (12.7 in)
Width	56 cm (22 in)	24.6 cm (9.7 in)	24.6 cm (9.7 in)
Depth	44.5 cm (18 in)	37.5 cm (14.75 in)	53.6 cm (21.1 in)
Weight	22 kg (50 lb)	11.3 kg (25 lb)	13.4 kg (29.5 lb)

Environmental	10 to 40°C, 80% RH
System Gas	Standard grade helium (99.7% pure)
Dispense Tips	304 SS, sapphire
Reagent Trays	Custom, deep well plates
Interface	Ethernet, Nanobuilder software GUI
Automation Control	Nanobuilder component library